Hydrochloric Acid → 1-(2,6-Dihydroxyphenyl)-2-methyl-1-propanone

HRID 527532ノート

反応式

HRID 527532 の反応式
COC[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11]COC)[C:6]=1[C:15](=[O:19])[CH:16]([CH3:18])[CH3:17].Cl>CO>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:6]=1[C:15](=[O:19])[CH:16]([CH3:17])[CH3:18]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 679585761-(2,6-Bis{[(methyloxy)methyl]oxy}phenyl)-2-methyl-1-propanone2 回

生成物 1

HCID 134833211-(2,6-Dihydroxyphenyl)-2-methyl-1-propanone収率 86.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1-(2,6-bis{[(methyloxy)methyl]oxy}phenyl)-2-methyl-1-propanone (Intermediate 36, 1.58 g, 5.89 mmol) was dissolved in methanol (40.0 ml) and an aqueous solution of HCl (23.6 mL of a 2M aqueous solution, 47.1 mmol) was added. The reaction mixture was refluxed for 1 hour. After quenching with water, the reaction mixture was extracted with ethyl acetate. The gathered organic layers were dried over sodium sulphate, filtered and evaporated to afford the title compound (916 mg).

後処理

  1. temperatureThe reaction mixture was refluxed for 1 hour
  2. customAfter quenching with water
  3. extractionthe reaction mixture was extracted with ethyl acetate
  4. dry with materialThe gathered organic layers were dried over sodium sulphate
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-cd3b80daa5fa4eb7989f5606870afe0e
出典データセット
uspto-grants-2016_05
特許番号
US09346790B2

反応ノート

読み込み中…