反応式
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([CH3:14])([CH3:13])[CH3:12])[C:6]=1[OH:15])([CH3:4])([CH3:3])[CH3:2].[C:16]([C:18]1[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=1)#[N:17].[NH:26]1[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>C1(C)C(C)=CC=CC=1>[C:11]([C:7]1[CH:8]=[C:9]([CH:22]([N:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]2)[C:21]2[CH:24]=[CH:25][C:18]([C:16]#[N:17])=[CH:19][CH:20]=2)[CH:10]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[C:6]=1[OH:15])([CH3:14])([CH3:13])[CH3:12]参加物
5
実験手順
2,6-Di-tert-butylphenol (4.12 g, 0.02 mol), 2.62 g (0.02 mol) of 4-cyano-benzaldehyde and 1.7 g (0.02 mol) of piperidine are refluxed under nitrogen in 25 ml of xylene for 24 hours. The solution is then evaporated in vacuo and the residue chromatographed on silica gel with toluene/ethyl acetate (9:1) to give 6.2 g of a practically pure title compound. A 5 g portion of said compound is recrystallized twice from acetonitrile to give 1.0 g of a pure sample as colorless crystals, melting at 139°-140° C.
後処理
- customThe solution is then evaporated in vacuo
- customthe residue chromatographed on silica gel with toluene/ethyl acetate (9:1)
出典と根拠
- ORDレコード
- ord-beda6d3011e24f9086c71fc392715617
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05616774
関連ノート
読み込み中…