BOC-D-alanine → 1,1-dimethylethyl {(1R)-1-[({6-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-3-pyridinyl}amino)carbonyl]propyl}carbamate
反応式
CC(N([C@H](C)C([NH:12][C:13]1[CH:14]=[N:15][C:16]([O:19][C:20]2[C:25]3[C:26]([CH3:30])([CH3:29])[CH2:27][O:28][C:24]=3[CH:23]=[CH:22][CH:21]=2)=[CH:17][CH:18]=1)=O)C(=O)[O-])(C)C.CC(OC(N[C@@H](C(O)=O)C)=O)(C)C.[CH3:45][C:46]([O:49][C:50]([NH:52][C@H:53]([CH2:57][CH3:58])[C:54]([OH:56])=O)=[O:51])([CH3:48])[CH3:47]>>[CH3:29][C:26]1([CH3:30])[C:25]2[C:20]([O:19][C:16]3[N:15]=[CH:14][C:13]([NH:12][C:54]([C@H:53]([NH:52][C:50](=[O:51])[O:49][C:46]([CH3:45])([CH3:47])[CH3:48])[CH2:57][CH3:58])=[O:56])=[CH:18][CH:17]=3)=[CH:21][CH:22]=[CH:23][C:24]=2[O:28][CH2:27]1参加物
4
反応物 3
生成物 1
実験手順
The title compound was made in a similar fashion to the preparation of Intermediate 60 replacing N-{[(1,1-dimethylethyl)oxy]carbonyl}-D-alanine with (2R)-2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)butanoic acid (66.6 mg). This afforded 78 mg of the title compound.