2,4,4-Trimethyl-5-[(5-nitro-2-pyridyl)oxy]-3,1-benzoxazine → 6-[(2,4,4-Trimethyl-3,1-benzoxazin-5-yl)oxy]pyridin-3-amine
反応式
[CH3:1][C:2]1[O:7][C:6]([CH3:9])([CH3:8])[C:5]2[C:10]([O:14][C:15]3[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][N:16]=3)=[CH:11][CH:12]=[CH:13][C:4]=2[N:3]=1>CCO>[CH3:1][C:2]1[O:7][C:6]([CH3:8])([CH3:9])[C:5]2[C:10]([O:14][C:15]3[N:16]=[CH:17][C:18]([NH2:21])=[CH:19][CH:20]=3)=[CH:11][CH:12]=[CH:13][C:4]=2[N:3]=1参加物
3
実験手順
To a solution of 2,4,4-trimethyl-5-[(5-nitro-2-pyridyl)oxy]-3,1-benzoxazine (Intermediate 203, 220 mg, 0.70 mmol) in EtOH (3 mL) palladium on carbon 10% w/w (25 mg) was added and the resulting mixture was stirred for 40 minutes under hydrogen atmosphere (2 bar) at room temperature. The catalyst was filtered off and washed with EtOH (3×10 mL). The filtrate was concentrated to the title compound (185 mg) as greenish solid.
後処理
- filtrationThe catalyst was filtered off