Benzene, 2-methoxy-1-methyl-4-nitro- → 3-Methoxy-4-methylaniline

HRID 527719

反応式

HRID 527719 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[O:11][CH3:12]>CO>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[O:11][CH3:12]

参加物

3

反応物 1

HCID 83159Benzene, 2-methoxy-1-methyl-4-nitro-

生成物 1

HCID 278823-Methoxy-4-methylaniline収率 90.6%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1-methyl-2-(methyloxy)-4-nitrobenzene (2.5 g, 14.96 mmol) in methanol (50 mL) Ni-Raney (˜2 g) was added and the reaction mixture was stirred overnight at room temperature under H2 atmosphere (1 atm). The catalyst was filtered off and the residue was purified by SCX cartridge (50 g) to afford the title compound (1.86 g) as a colourless oil.

後処理

  1. filtrationThe catalyst was filtered off
  2. customthe residue was purified by SCX cartridge (50 g)

出典と根拠

ORDレコード
ord-f265de6e7e6f4015b51a458380e9583b
出典データセット
uspto-grants-2016_05
特許番号
US09346790B2

関連ノート

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