Diisopropylethylamine → HCID 178485620、化合物

関与物質

役割	名称	HCID	仕込み量
反応物	Diisopropylethylamine	HCID 81531	—
反応物	Imidazole-4-acetic acid	HCID 96215	—
反応物	O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate	HCID 2733207	—
反応物	(R)-N-methyl-1-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine	HCID 66765875	—
溶媒	Tetrahydrofuran	HCID 8028	—
生成物	HCID 178485620	HCID 178485620	—

反応手順

To a solution of (R)—N-methyl-1-(7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine (0.29 mmol), TBTU (0.35 mmol) and DIPEA (0.58 mmol) in THF was slowly added 2-(1H-imidazol-4-yl)acetic acid (0.29 mmol). The mixture was stirred at room temperature overnight, then concentrated, diluted with water, and extracted with EtOAc. The combined extracts were dried, filtered and concentrated. The residue was purified by flash chromatography to give the title compound.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US09346810B2
出典データセット	uspto-grants-2016_05
ORD ID	ord-2d213c21ff16469e87bc93c1891701c0
出典メモ	uspto-grants-2016_05