Hydrochloric Acid → HCID 86711709、化合物

反応式

C[O:2][C:3]1[C:12](=O)[N:11]([CH3:14])[C:10]2[N:9]=[CH:8][N:7]=[C:6]([N:15]3[CH2:31][CH2:30][C:18]4([N:22]([C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH2:21][NH:20][C:19]4=[O:29])[CH2:17][CH2:16]3)[C:5]=2[N:4]=1.[OH2:32].[OH-].[Li+].Cl>O>[CH3:14][N:11]1[C:12]([C:3]([OH:32])=[O:2])=[N:4][C:5]2[C:10]1=[N:9][CH:8]=[N:7][C:6]=2[N:15]1[CH2:31][CH2:30][C:18]2([N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:21][NH:20][C:19]2=[O:29])[CH2:17][CH2:16]1

参加物

反応条件

温度: 60 °C

実験手順

6-Methoxy-8-methyl-4-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)pteridin-7(8H)-one (1 g, 2.37 mmol) was treated with lithium hydroxide monohydrate (0.281 g, 4.74 mmol) tetrahydrofuran (2.5 mL) and water (2.5 mL). This mixture was stirred at 60° C. for 48 hours. The reaction mixture was cool to room temperature acidified to pH 4 with 1 M hydrochloric acid (8 mL) and evaporated under reduced pressure. The resulting crude material was then used in the next step without any further purification. MS (EI) for C20H21N7O3: 408 (MH+), 364 (MH+−44 (—CO2)).