Imidazole → N-[(Phenylmethoxy)carbonyl]-O-[(1,1-dimethylethyl)dimethlsilyl]-L-homoserine

HRID 52805

反応式

HRID 52805 の反応式
[C:1]1([CH2:7][O:8][C:9]([NH:11][C@H:12]([C:16]([OH:18])=[O:17])[CH2:13][CH2:14][OH:15])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:19][C:20]([Si:23](Cl)([CH3:25])[CH3:24])([CH3:22])[CH3:21].N1C=CN=C1>CN(C)C=O.CO>[C:1]1([CH2:7][O:8][C:9]([NH:11][C@H:12]([C:16]([OH:18])=[O:17])[CH2:13][CH2:14][O:15][Si:23]([C:20]([CH3:22])([CH3:21])[CH3:19])([CH3:25])[CH3:24])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 489187Cbz-L-Homoserine

生成物 1

HCID 54368725N-[(Phenylmethoxy)carbonyl]-O-[(1,1-dimethylethyl)dimethlsilyl]-L-homoserine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6228Dimethylformamide溶媒

実験手順

A solution of N-[(phenylmethoxy)carbonyl]-L-homoserine [prepared as described in Example 6(a), 3.0 g., 11.85 mmol.] in dry dimethylformamide (65 ml.) was treated with [(1,1-dimethylethyl)dimethylsilyl chloride (10.72 g., 71.1 mmol.) and imidazole (9.65 g, 0.14 mol.) and stirred at room temperature under argon for 24 hours. The reaction mixture was diluted with methanol (207 ml.), stirred for another 24 hours at room temperature and then concentrated to a syrup. The residual syrup was dissolved in ethyl acetate (200 ml.), washed with 10% citric acid (2×75 ml) and brine, dried (anhydrous sodium sulfate), filtered, evaporated to dryness and dried in vacuo. The crude product mixture was chromatographed on a silica gel column (Merck), eluting the column with ethyl acetate:hexane (1:1) followed by ethyl acetate:acetic acid (99.5:0.5). The desired fractions were combined, concentrated and evaporated several times from toluene to give 3.56 g. of title compound as a waxy solid. TLC(ethyl acetate:acetic acid, 95:5) Rf =0.82.

後処理

  1. stirringstirred for another 24 hours at room temperature
  2. concentrationconcentrated to a syrup
  3. dissolutionThe residual syrup was dissolved in ethyl acetate (200 ml.)
  4. washwashed with 10% citric acid (2×75 ml) and brine
  5. dry with materialdried (anhydrous sodium sulfate)
  6. filtrationfiltered
  7. customevaporated to dryness
  8. customdried in vacuo
  9. customThe crude product mixture was chromatographed on a silica gel column (Merck)
  10. washeluting the column with ethyl acetate:hexane (1:1)
  11. concentrationconcentrated
  12. customevaporated several times from toluene
  13. customto give 3.56 g

出典と根拠

ORDレコード
ord-7398ffe7009c460da617b0f483d53c9c
出典データセット
uspto-grants-1997_04
特許番号
US05616775

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