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1H-indazol-7-amine → N2,N4-bis(7-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1H-indazol-7-amine | HCID 88901 | — |
| 反応物 | Ethyl 2,4-dichloropyrimidine-5-carboxylate | HCID 104020 | — |
| 生成物 | N2,N4-bis(7-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine | HCID 22060714 | — |
反応手順
In like manner to N2,N4-bis(3-hydroxyphenyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine, 2,4-dichloro-5-ethoxycarbonylpyrimidine and 7-aminoindazole were reacted to yield N2,N4-bis(7-indazolyl)-5-ethoxycarbonyl-2,4-pyrimidinediamine. 1H NMR (DMSO-d6): δ 8.70 (s, 1H), 7.54 (d, 2H J=8.4 Hz), 7.37 (m, 6H), 4.3 (q, 2H, J=7.0 Hz), 1.33 (3H, J=7 Hz); LCMS: ret. time 23.61 min.; purity: 94%; MS (m/e): 415 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09346765B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-b1507e5e1f544a309f9d111b3ccba7f5 |
| 出典メモ | uspto-grants-2016_05 |