1-Butanol → 2-(6-Octyloxy-2-naphthyl)-5-butylbenzooxazole

HRID 5284

反応式

HRID 5284 の反応式
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]1[O:13][C:14]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][CH3:24])=[CH:17][C:15]=3[N:16]=1)[CH:6]=[CH:5]2.[CH2:25](I)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32].[OH-].[K+].C(O)CCC>O>[CH2:25]([O:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]1[O:13][C:14]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][CH3:24])=[CH:17][C:15]=3[N:16]=1)[CH:6]=[CH:5]2)[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]

参加物

6

反応物 4

HCID 2631-ButanolHCID 123801-IodooctaneHCID 14797Potassium HydroxideHCID 1357271132-(6-Hydroxy-2-naphthyl)-5-butylbenzooxazole

生成物 1

HCID 197954142-(6-Octyloxy-2-naphthyl)-5-butylbenzooxazole収率 56.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a 30ml round-bottom flask, 0.47 g (1.48 m mole) of 2-(6-hydroxy-2-naphthyl)-5-butylbenzooxazole, 0.43 g (1.79 m mole) of octyl iodide, 0.12 g (1.82 m mole) of potassium hydroxide and 5 ml of butanol were placed, followed by refluxing for 310 minutes. The reaction mixture was poured into water, extracted from ethyl acetate to obtain an organic layer. The organic layer was washed with water dried with mirabilite and dried under reduced pressure to obtain a resultant. The resultant was recrystallized from ethylacetate to obtain a crystal. The crystal was filtered, purified by silica gel column chromatography (eluent: toluene) and recrystallized from acetone to obtain 0.36 g of 2-(6-octyloxy-2-naphthyl)-5-butylbenzooxazole (Yield: 56.6%). ##STR190##

後処理

  1. temperatureby refluxing for 310 minutes
  2. extractionextracted from ethyl acetate
  3. customto obtain an organic layer
  4. washThe organic layer was washed with water
  5. dry with materialdried with mirabilite
  6. customdried under reduced pressure
  7. customto obtain a resultant
  8. customThe resultant was recrystallized from ethylacetate
  9. customto obtain a crystal
  10. filtrationThe crystal was filtered
  11. custompurified by silica gel column chromatography (eluent: toluene)
  12. customrecrystallized from acetone

出典と根拠

ORDレコード
ord-b2461ebc65244f8f8d1cf4f61ec82c12
出典データセット
uspto-grants-1993_09
特許番号
US05244596

関連ノート

読み込み中…