N-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-amine → 4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

HRID 528524

反応式

HRID 528524 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][O:15][C:14]2[CH:18]=[C:19]([S:22](Cl)(=[O:24])=[O:23])[CH:20]=[CH:21][C:13]1=2.[CH3:26][O:27][C:28]1[CH:40]=[CH:39][C:31]([CH2:32][NH:33][C:34]2[S:35][CH:36]=[CH:37][N:38]=2)=[CH:30][CH:29]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][O:15][C:14]2[CH:18]=[C:19]([S:22]([N:33]([CH2:32][C:31]3[CH:39]=[CH:40][C:28]([O:27][CH3:26])=[CH:29][CH:30]=3)[C:34]3[S:35][CH:36]=[CH:37][N:38]=3)(=[O:24])=[O:23])[CH:20]=[CH:21][C:13]1=2

参加物

3

反応物 2

HCID 578640N-[(4-methoxyphenyl)methyl]-1,3-thiazol-2-amineHCID 897617224-(2-chloro-4-(trifluoromethyl)phenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride

生成物 1

HCID 897617974-(2-chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

実験手順

4-(2-chloro-4-(trifluoromethyl)phenyl)-N-(4-methoxybenzyl)-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide (INTERMEDIATE X) was prepared in the same manner as INTERMEDIATE D, STEP 3, except employing INTERMEDIATE E and INTERMEDIATE W (N-(4-methoxybenzyl)thiazol-2-amine) m/z (ESI) 595.8 (M+H)+.

出典と根拠

ORDレコード
ord-7a04a9f9cab54a2e966ebf8f48210abf
出典データセット
uspto-grants-2016_05
特許番号
US09346798B2

関連ノート

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