Hydrochloric Acid → 4,4-Difluoro-perhydro-azepinium chloride

HRID 528780ノート

反応式

HRID 528780 の反応式
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][C:11]([F:16])([F:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:17]>>[Cl-:17].[F:15][C:11]1([F:16])[CH2:12][CH2:13][CH2:14][NH2+:8][CH2:9][CH2:10]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 58110242Tert-butyl 4,4-difluoroazepane-1-carboxylate

生成物 1

HCID 674556284,4-Difluoro-perhydro-azepinium chloride

実験手順

To 830 mg (3.53 mmol) of 4,4-Difluoro-perhydro-azepine-1-carboxylic acid tert-butyl ester was added 5 mL of 2 M aq. HCl and stirring was continued overnight at room temperature. The reaction mixture was freeze dried and used for the next step without further purification

後処理

  1. customdried
  2. customused for the next step without further purification

出典と根拠

ORDレコード
ord-e2a839af5d554d9aadeda1c107cbe790
出典データセット
uspto-grants-2016_05
特許番号
US09346816B2

反応ノート

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