化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → 8-(4-(Methoxycarbonyl)benzyloxy)naphthalene-2-sulfonic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Methyl 4-(bromomethyl)benzoate | HCID 256687 | — |
| 反応物 | 1-Hydroxynaphthalene-7-sulfonic acid | HCID 3022482 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 8-(4-(Methoxycarbonyl)benzyloxy)naphthalene-2-sulfonic acid | HCID 86718862 | 32.9% |
反応手順
8-Hydroxynaphthalene-2-sulfonic acid (110 mg, 0.49 mmol), KOH (110 mg, 1.96 mmol), methyl 4-(bromomethyl)benzoate (112 mg, 0.49 mmol) and NaI (7.4 mg, 0.49 mmol) were stirred in DMF (1.0 mL) at room temperature for 1 h and then at 60° C. for 72 h. The reaction mixture was cooled to room temperature, diluted with water and purified using preparative HPLC to give the title compound (60 mg, 31%). MS(ESI−) m/z 371.3 (M−H)−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09346795B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-c1469fe480854a028fb71a34a8496dcc |
| 出典メモ | uspto-grants-2016_05 |