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Benzoyl chloride, 3,4-dichloro- → 1-(3,4-Dichlorobenzoyl)indoline-5-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoyl chloride, 3,4-dichloro- | HCID 76403 | — |
| 反応物 | 2,3-dihydro-1H-indole-5-sulfonamide | HCID 8027252 | — |
| 反応物 | 1-(Cyclohexanecarbonyl)indoline-5-sulfonamide | HCID 60698742 | — |
| 生成物 | 1-(3,4-Dichlorobenzoyl)indoline-5-sulfonamide | HCID 71060764 | 36.3% |
反応手順
Following a procedure analogous to that for the synthesis of Intermediate 55, indoline-5-sulfonamide (Intermediate 54A, 195 mg, 0.98 mmol) and 3,4-dichlorobenzoyl chloride (412 mg, 1.97 mmol) were converted to the title compound (132 mg, 36%) after purification using preparative HPLC. 1H NMR (DMSO-d6) δ 7.92 (d, J=1.1 Hz, 1H), 7.78 (d, J=8.1 Hz, 1H), 7.71-7.61 (m, 3H), 7.26 (s, 2H), 4.07 (t, J=8.3 Hz, 2H), 3.16 (t, J=8.2 Hz, 2H); MS(ESI+) m/z 370.8 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09346795B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-eba422339fb24e8b99caeb21989720c3 |
| 出典メモ | uspto-grants-2016_05 |