1-ethyl-2,3-dihydro-1H-indole-5-sulfonamide → 1-(3,4-Dichlorobenzyl)indoline-5-sulfonamide

関与物質

反応手順

Following a procedure analogous to that for the synthesis of Intermediate 53, 1-(3,4-dichlorobenzoyl)indoline-5-sulfonamide (Intermediate 58, 70 mg, 0.19 mmol) was converted to the title compound (41 mg, 61%) after purification using preparative HPLC. 1H NMR (DMSO-d6) δ 7.63-7.58 (m, 2H), 7.48-7.43 (m, 2H), 7.31 (dd, J=8.3, 2.1 Hz, 1H), 6.91 (s, 2H), 6.60 (d, J=8.1 Hz, 1H), 4.41 (s, 2H), 3.46 (t, J=8.7 Hz, 2H), 3.03-2.98 (m, 2H); MS(ESI+) m/z 356.9 (M+H)+.

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