(Phenylthio)acetic acid → 1-(2-(Phenylthio)acetyl)indoline-5-sulfonamide

HRID 528833

反応式

HRID 528833 の反応式
ClC1C=C([CH2:9][C:10]([N:12]2[C:20]3[C:15](=[CH:16][C:17]([S:21]([NH2:24])(=[O:23])=[O:22])=[CH:18][CH:19]=3)[CH2:14][CH2:13]2)=[O:11])C=CC=1Cl.N1[C:33]2[C:28](=[CH:29][C:30]([S:34](N)(=O)=O)=[CH:31][CH:32]=2)CC1.C1(SCC(O)=O)C=CC=CC=1>>[C:30]1([S:34][CH2:9][C:10]([N:12]2[C:20]3[C:15](=[CH:16][C:17]([S:21]([NH2:24])(=[O:22])=[O:23])=[CH:18][CH:19]=3)[CH2:14][CH2:13]2)=[O:11])[CH:31]=[CH:32][CH:33]=[CH:28][CH:29]=1

参加物

4

反応物 3

HCID 59541(Phenylthio)acetic acidHCID 80272522,3-dihydro-1H-indole-5-sulfonamide2 回HCID 710610531-(2-(3,4-Dichlorophenyl)acetyl)indoline-5-sulfonamide

生成物 1

HCID 710607121-(2-(Phenylthio)acetyl)indoline-5-sulfonamide収率 45%

実験手順

Following a procedure analogous to that for the synthesis of Intermediate 64, indoline-5-sulfonamide (Intermediate 54A, 120 mg, 0.60 mmol) and 2-(phenylthio)acetic acid (117 mg, 0.70 mmol) were converted to the title compound (100 mg, 45%). 1H NMR (DMSO-d6) δ 8.09 (d, J=8.4 Hz, 1H), 7.67-7.62 (m, 2H), 7.43-7.40 (m, 2H), 7.34-7.30 (m, 2H), 7.22-7.19 (m, 3H), 4.29 (t, J=8.6 Hz, 2H), 4.17 (s, 2H), 3.23 (t, J=8.5 Hz, 2H); MS(ESI+) m/z 348.9 (M+H)+.

出典と根拠

ORDレコード
ord-eddafac2e563419bab44774925c1d4e0
出典データセット
uspto-grants-2016_05
特許番号
US09346795B2

関連ノート

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