Butanal → N-(3-Isopropoxybenzyl)butan-1-amine

関与物質

反応手順

Following a procedure analogous to that for the synthesis of Example 106, (3-isopropoxyphenyl)methanamine (Matrix, 200 mg, 1.21 mmol) and butyraldehyde (110 μL, 1.21 mmol) were converted to the title compound (43 mg, 16%). 1H NMR (CDCl3) δ 7.29-7.17 (m, 1H), 6.99-6.74 (m, 3H), 4.57 (td, J=6.1, 12.1 Hz, 1H), 3.80 (s, 2H), 2.65 (t, J=7.3 Hz, 2H), 1.63-1.50 (m, 2H), 1.40-1.24 (m, 8H), 0.90 (t, J=7.3 Hz, 3H); MS (ESI+) m/z 222.2 (M+H)+.

情報源と証拠