Butanal → N-butyl-4-methoxyaniline
反応式
[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.[CH:10](=O)[CH2:11][CH2:12][CH3:13]>>[CH2:10]([NH:7][C:6]1[CH:8]=[CH:9][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[CH2:11][CH2:12][CH3:13]参加物
3
実験手順
Following a procedure analogous to that for the synthesis of Intermediate 137, 4-methoxyaniline (500 mg, 4.06 mmol) and butyraldehyde (360 μL, 4.06 mmol) were converted to the title compound (700 mg, 88%). 1H NMR (CDCl3) δ 6.89-6.73 (m, 2H), 6.69-6.50 (m, 2H), 3.76 (s, 3H), 3.10 (t, J=7.2 Hz, 2H), 1.70-1.28 (m, 4H), 1.02-0.90 (m, 3H); MS(ESI+) m/z 180.1 (M+H)+.
出典と根拠
- ORDレコード
- ord-1c91ccc07e004924abd167c0d911b4e2
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09346795B2
反応ノート
読み込み中…