Butanal → HCID 71086468、化合物

反応式

[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([NH2:14])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[CH:15](=O)[CH2:16][CH2:17][CH3:18]>>[CH2:15]([NH:14][C:10]1[CH:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[CH:13]=[CH:12][CH:11]=1)[CH2:16][CH2:17][CH3:18]

参加物

反応物 2

HCID 261Butanal

HCID 27574253-(3-Chlorophenyl)aniline

生成物 1

HCID 71086468HCID 71086468、化合物

実験手順

Following a procedure analogous to that for the synthesis of Intermediate 137, 3′-chlorobiphenyl-3-amine (Oakwood, 15 mg, 0.074 mmol) and butyraldehyde (7 μL, 0.074 mmol) were converted to a crude oil which was used without purification in the preparation of Example 143. 1H NMR (CDCl3) δ 8.17 (d, J=0.9 Hz, 1H), 7.86-7.42 (m, 3H), 7.41-7.07 (m, 3H), 6.78-6.57 (m, 1H), 3.00-2.87 (m, 2H), 1.63-1.46 (m, 2H), 1.47-1.34 (m, 2H), 1.02 (t, J=7.4 Hz, 3H); MS(ESI+) m/z 260.2 (M+H)+.

後処理

customwas used without purification in the preparation of Example 143

出典と根拠

ORDレコード: ord-b08f05c785f54d10911c7a2434e337d0
出典データセット: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09346795B2

反応ノート

読み込み中…

参加物