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N,N-dibutyl-4-chloro-5-methyl-1H-pyrazole-3-carboxamide → N,N-Dibutyl-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole-3-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-dibutyl-4-chloro-5-methyl-1H-pyrazole-3-carboxamide | HCID 71062189 | — |
| 反応物 | Ethyl 5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole-3-carboxylate | HCID 71062309 | — |
| 生成物 | N,N-Dibutyl-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole-3-carboxamide | HCID 71062468 | 83% |
反応手順
Following a procedure analogous to that for the synthesis of Intermediate 1B, ethyl 5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole-3-carboxylate (2.15 g, 8.01 mmol) was converted to the title compound (2.35 g, 83%). MS(ESI+) m/z 352.4 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09346795B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-283cc6188a734fbb81716f84ca8a64f2 |
| 出典メモ | uspto-grants-2016_05 |