ethyl 4-chloro-5-methyl-1H-pyrazole-3-carboxylate → N,N-dibutyl-4-chloro-5-methyl-1H-pyrazol-3-amine

関与物質

反応手順

Following a procedure analogous to that for the synthesis of Intermediate 1A, N,N-dibutyl-5-methyl-1H-pyrazol-3-amine (419 mg, 2.00 mmol) was converted to the title compound (297 mg, 61%). 1H NMR (CDCl3) δ 3.26-3.17 (m, 4H), 2.19 (s, 3H), 1.57-1.44 (m, 4H), 1.32 (qd, J=15.0, 7.3 Hz, 4H), 0.91 (t, J=7.4 Hz, 6H); MS(ESI+) m/z 243.9 (M+H)+.

情報源と証拠