4-(4-(Dibutylcarbamoyl)-1-methyl-1H-imidazol-2-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoic acid → 4-(4-(dibutylcarbamoyl)-1-methyl-1H-imidazol-5-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoic acid
反応式
C(N(CCCC)C(C1N=C(C2C=CC(C(O)=O)=CC=2C(N2CCC3C(=CC=CC=3)C2)=O)N(C)C=1)=O)CCC.[CH2:39]([N:43]([CH2:74][CH2:75][CH2:76][CH3:77])[C:44]([C:46]1[N:47]=[CH:48][N:49]([CH3:73])[C:50]=1[C:51]1[CH:60]=[CH:59][C:54]([C:55]([O:57]C)=[O:56])=[CH:53][C:52]=1[C:61]([N:63]1[CH2:72][CH2:71][C:70]2[C:65](=[CH:66][CH:67]=[CH:68][CH:69]=2)[CH2:64]1)=[O:62])=[O:45])[CH2:40][CH2:41][CH3:42]>>[CH2:39]([N:43]([CH2:74][CH2:75][CH2:76][CH3:77])[C:44]([C:46]1[N:47]=[CH:48][N:49]([CH3:73])[C:50]=1[C:51]1[CH:60]=[CH:59][C:54]([C:55]([OH:57])=[O:56])=[CH:53][C:52]=1[C:61]([N:63]1[CH2:72][CH2:71][C:70]2[C:65](=[CH:66][CH:67]=[CH:68][CH:69]=2)[CH2:64]1)=[O:62])=[O:45])[CH2:40][CH2:41][CH3:42]参加物
3
反応物 2
生成物 1
実験手順
Following a procedure analogous to that for the synthesis of Intermediate 264L, methyl 4-(4-(dibutylcarbamoyl)-1-methyl-1H-imidazol-5-yl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (400 mg, 0.75 mmol) was converted to the title compound (300 mg, 77%). MS(ESI+) m/z 517.6 (M+H)+.