Hydrochloric Acid → HCID 178440151、化合物

HRID 52907ノート

反応式

HRID 52907 の反応式
[OH:1][CH2:2][C:3]1[N:4]=[C:5]([CH2:31][CH2:32][CH3:33])[N:6]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:7]=1[C:8]([O:10]CC)=[O:9].O.[OH-].[Li+].Cl>O>[OH:1][CH2:2][C:3]1[N:4]=[C:5]([CH2:31][CH2:32][CH3:33])[N:6]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:18][CH:19]=2)[C:7]=1[C:8]([OH:10])=[O:9]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 178440150HCID 178440150、化合物

生成物 1

HCID 178440151HCID 178440151、化合物収率 80%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 0.20 g of ethyl 4-hydroxymethyl-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 35(c)] and 0.10 g of lithium hydroxide monohydrate in 3 ml of water was stirred at room temperature for 3 hours, after which it was allowed to stand for 16 hours at the same temperature. The reaction mixture was then mixed with 2.38 ml of 1N aqueous hydrochloric acid and the resulting precipitate was collected by filtration, to give 150 mg of the title compound, melting a=233° C. (with decomposition).

後処理

  1. waitto stand for 16 hours at the same temperature
  2. filtrationthe resulting precipitate was collected by filtration

出典と根拠

ORDレコード
ord-4cf08a5710a44f68a929c2adcc952f18
出典データセット
uspto-grants-1997_04
特許番号
US05616599

反応ノート

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