3-Methoxy-6-methyl-2-nitropyridine → 3-Methoxy-6-methylpyridin-2-amine

HRID 529170

反応式

HRID 529170 の反応式
[CH3:1][O:2][C:3]1[C:4]([N+:10]([O-])=O)=[N:5][C:6]([CH3:9])=[CH:7][CH:8]=1>C(O)C.[C].[Pd]>[NH2:10][C:4]1[C:3]([O:2][CH3:1])=[CH:8][CH:7]=[C:6]([CH3:9])[N:5]=1

参加物

4

反応物 1

HCID 27279653-Methoxy-6-methyl-2-nitropyridine

生成物 1

HCID 167403823-Methoxy-6-methylpyridin-2-amine収率 91.4%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

To a solution of 3-methoxy-6-methyl-2-nitropyridine (3.85 g) in ethanol (91.6 ml) was added 10% palladium-carbon (50% wet, 0.96 g), and the mixture was stirred under hydrogen atmosphere for 2 hours. The catalyst was filtered off, and the filtrate was concentrated to dryness. The residue was recrystallized from ethyl acetate/hexane to give the title compound (2.89 g).

後処理

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated to dryness
  3. customThe residue was recrystallized from ethyl acetate/hexane

出典と根拠

ORDレコード
ord-6cbb3e4bf95f471493484a34f2eeafc9
出典データセット
uspto-grants-2016_05
特許番号
US09346822B2

関連ノート

読み込み中…