Allylamine → Tert-butyl 2-[(prop-2-en-1-yl)amino]acetate

HRID 529209ノート

反応式

HRID 529209 の反応式
[CH2:1]([NH2:4])[CH:2]=[CH2:3].[C:5]([O:9][C:10](=[O:13])[CH2:11]Br)([CH3:8])([CH3:7])[CH3:6]>ClCCl>[C:5]([O:9][C:10](=[O:13])[CH2:11][NH:4][CH2:1][CH:2]=[CH2:3])([CH3:8])([CH3:7])[CH3:6]

参加物

4

反応物 2

HCID 7853AllylamineHCID 79177tert-Butyl bromoacetate

生成物 1

HCID 19959470Tert-butyl 2-[(prop-2-en-1-yl)amino]acetate収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

Allylamine (10 mL, 0.13 mol) was cooled to 0° C., a solution of bromoacetic acid tert-butyl ester (1.0 mL, 6.7 mmol) in dichloromethane (10 ml) was slowly added. After stirring at 0° C. for 3 hours, the reaction mixture was concentrated under reduced pressure. The obtained residue was dissolved in diethyl ether, washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine, and dried over anhydrous sodium sulfate. The obtained solution was concentrated under reduced pressure to give the title compound as a yellow liquid (1.15 g, 6.7 mmol, 99%).

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. dissolutionThe obtained residue was dissolved in diethyl ether
  3. washwashed successively with saturated aqueous sodium hydrogen carbonate and saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationThe obtained solution was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-1084415a61834095a6a4dafcc7357bb9
出典データセット
uspto-grants-2016_05
特許番号
US09346821B2

反応ノート

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