N-((9H-Fluoren-9-ylmethoxy)carbonyl)-S-(triphenylmethyl)-L-cysteine → (3R,9aS)-3-Aminohexahydropyrido[2,1-b][1,3]thiazin-4(6H)-one

関与物質

反応手順

(3R,9aS)-3-Aminohexahydropyrido[2,1-b][1,3]thiazin-4(6H)-one (350 mg, 1.879 mmol) was synthesized as described for the preparation of Intermediate 30 using (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(tritylthio)propanoic acid in step A. 1H NMR (500 MHz, CD3OD) δ ppm 4.66-4.58 (m, 1H), 4.51 (dd, J=11.55, 2.75 Hz, 1H), 4.20 (dd, J=11.27, 5.22 Hz, 1H), 3.28-3.22 (m, 1H), 3.01 (dd, J=13.20, 4.95 Hz, 1H), 2.81 (td, J=12.65, 2.75 Hz, 1H), 2.10-1.99 (m, 1H), 1.95 (d, J=7.15 Hz, 2H), 1.82-1.71 (m, 1H), 1.67 (d, J=13.75 Hz, 1H), 1.53-1.41 (m, 1H); 13C NMR (126 MHz, CD3OD) δ ppm 165.13, 60.06, 52.13, 47.02, 35.88, 25.73, 25.18, 24.71.

情報源と証拠