Acetic Acid → HCID 178440143、化合物

HRID 52970ノート

反応式

HRID 52970 の反応式
[OH:1][CH:2]([C:7]1[N:8]=[C:9]([CH2:51][CH2:52][CH3:53])[N:10]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[N:31](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:11]=1[C:12]#[N:13])[C:3]([CH3:6])([CH3:5])[CH3:4].C(O)(=O)C>O>[OH:1][CH:2]([C:7]1[N:8]=[C:9]([CH2:51][CH2:52][CH3:53])[N:10]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:11]=1[C:12]#[N:13])[C:3]([CH3:6])([CH3:4])[CH3:5]

参加物

4

反応物 2

HCID 176Acetic AcidHCID 190362484-(1-Hydroxy-2,2-dimethyl propyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carbonitrile

生成物 1

HCID 178440143HCID 178440143、化合物収率 99.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

A suspension of 1.65 g of 4-(1-hydroxy-2,2-dimethyl propyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carbonitrile [prepared as described in step (b) above] in 24 ml of 75% v/v aqueous acetic acid was stirred at 60° C. for 2 hours. At the end of this time, 6 ml of water was added to the reaction mixture, which was then cooled with ice. The trityl alcohol which precipitated was removed by filtration, and the filtrate was concentrated by evaporation under reduced pressure, to give 1.07 g of the title compound as a glass.

後処理

  1. temperaturewas then cooled with ice
  2. customThe trityl alcohol which precipitated
  3. customwas removed by filtration
  4. concentrationthe filtrate was concentrated by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-6450204ed6c040318bf70c6c9035647e
出典データセット
uspto-grants-1997_04
特許番号
US05616599

反応ノート

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