Bromine → HCID 86668389、化合物
反応式
[Br:1]Br.[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([O:18][CH3:19])=[C:8]([C:10](=[O:17])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH:9]=1>O1CCOCC1>[Br:1][CH:11]([C:10]([C:8]1[CH:9]=[C:4]([Cl:3])[CH:5]=[CH:6][C:7]=1[O:18][CH3:19])=[O:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13]参加物
4
実験手順
Bromine (0.70 mL, 13.6 mmol) was added to a solution of ethyl 3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate (3.39 g, 13.2 mmol) in dioxane (25 mL) and stirred for 1 hour. The reaction was poured onto ice water, extracted with ethyl acetate, the organics washed with water and brine and evaporated to dryness to give ethyl 2-bromo-3-(5-chloro-2-methoxyphenyl)-3-oxopropanoate. LCMS (method 1) [M+H]+=337.2, RT=3.84 min.
後処理
- additionThe reaction was poured onto ice water
- extractionextracted with ethyl acetate
- washthe organics washed with water and brine
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-539acebd4d4549e8b918e127997c0aaa
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09346815B2
反応ノート
読み込み中…