4-(1-Hydroxy-2-methylpropyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carbonitrile → HCID 178440147、化合物

HRID 52978ノート

反応式

HRID 52978 の反応式
[OH:1][CH:2]([C:6]1[N:7]=[C:8]([CH2:50][CH2:51][CH3:52])[N:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[N:30](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:10]=1[C:11]#[N:12])[CH:3]([CH3:5])[CH3:4]>C(O)(=O)C>[OH:1][CH:2]([C:6]1[N:7]=[C:8]([CH2:50][CH2:51][CH3:52])[N:9]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:10]=1[C:11]#[N:12])[CH:3]([CH3:5])[CH3:4]

参加物

3

反応物 1

HCID 190361994-(1-Hydroxy-2-methylpropyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carbonitrile

生成物 1

HCID 178440147HCID 178440147、化合物収率 99.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Following a procedure similar to that described in Example 74(c), but using 1.36 g of 4-(1-hydroxy-2-methylpropyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carbonitrile [prepared as described in step (b) above] in 75% v/v aqueous acetic acid, 0.87 g of the title compound was obtained as a glass.

出典と根拠

ORDレコード
ord-5e2d76c7a30c4bab988e902d71c062d4
出典データセット
uspto-grants-1997_04
特許番号
US05616599

反応ノート

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