化工社化工社 化学情報印刷レポート · 研究参考用
Ethanol → Ethyl 5-ethoxy-1H-pyrazole-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Ethyl 4,4,4-trichloro-3-oxobutyrate | HCID 77294 | — |
| 反応物 | Hydrazinium chloride | HCID 115031 | — |
| 生成物 | Ethyl 5-ethoxy-1H-pyrazole-3-carboxylate | HCID 68571888 | — |
反応手順
4,4,4-Trichloro-3-oxo-butyric acid ethyl ester (Int 8, 1 eq) and H2NNH2.HCl (1.1 eq) are mixed in EtOH. The resulting mixture is refluxed overnight. The mixture is then evaporated and the obtained crude is purified by chromatography to give Int 9 and 5-ethoxy-2H-pyrazole-3-carboxylic acid ethyl ester (Int 10).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09351955B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-71b12c252fd04dada538bd59c20bb483 |
| 出典メモ | uspto-grants-2016_05 |