Sulfuric Acid → O-benzyl-N-(4,6-bis-propylamino-[1,3,5]triazin-2-yl)-N-methyl-hydroxylamine hydrogen sulfate
反応式
[CH2:1]([O:8][N:9]([C:11]1[N:16]=[C:15]([NH:17][CH2:18][CH2:19][CH3:20])[N:14]=[C:13]([NH:21][CH2:22][CH2:23][CH3:24])[N:12]=1)[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:25][S:26]([OH:29])(=[O:28])=[O:27]>>[S:26]([OH:29])([OH:28])(=[O:27])=[O:25].[CH2:1]([O:8][N:9]([C:11]1[N:12]=[C:13]([NH:21][CH2:22][CH2:23][CH3:24])[N:14]=[C:15]([NH:17][CH2:18][CH2:19][CH3:20])[N:16]=1)[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
3
実験手順
O-Benzyl-N-(4,6-bis-propylamino-[1,3,5]triazin-2-yl)-N-methyl-hydroxylamine (LIII) was reacted with 95% H2SO4 as described in Example 20 to yield O-benzyl-N-(4,6-bis-propylamino-[1,3,5]triazin-2-yl)-N-methyl-hydroxylamine hydrogen sulfate (LIV) in quantitative yield. 400 MHz 1H NMR (DMSO-d6, ppm) 12.0-10.9 (1H, br s), 8.7-8.3 (1H, br s), 7.56-7.46 (2H, m), 7.46-7.37 (2.5H, m), 7.36-7.30 (0.5H, m), 5.07-4.95 (2H, m), 3.44-3.16 (7H, m), 1.61-1.45 (4H, m), 0.94-0.82 (6H, m). ESI-MS (m/z): 331 [M+H]+.
出典と根拠
- ORDレコード
- ord-5c617a2f30234bd4b529f758877d40a5