4-Acetyl-2-butyl-5-cyano-1-tritylimidazole → HCID 178441657、化合物
反応式
[C:1]([C:4]1[N:5]=[C:6]([CH2:30][CH2:31][CH2:32][CH3:33])[N:7](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[C:8]=1[C:9]#[N:10])(=[O:3])[CH3:2]>C(O)(=O)C>[C:1]([C:4]1[N:5]=[C:6]([CH2:30][CH2:31][CH2:32][CH3:33])[NH:7][C:8]=1[C:9]#[N:10])(=[O:3])[CH3:2]参加物
3
反応条件
- 温度
- 60 °C
実験手順
A suspension of 1.78 g of 4-acetyl-2-butyl-5-cyano-1-tritylimidazole [prepared as described in step (ii) above] in 80% v/v aqueous acetic acid was stirred at 60° C. for 1 hour. The solution thus obtained was concentrated to dryness by evaporation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 3:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 0.66 g of the title compound as a colorless solid, melting at 77°-78° C.