Einecs 211-027-4 → HCID 178431895、化合物

HRID 530757ノート

反応式

HRID 530757 の反応式
C[O:2][C:3]1[CH:8]=[C:7]([C:9]2[S:10][CH:11]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:13]=2)[N:6]=[C:5]([C:18]2[S:19][CH:20]=[C:21]([CH3:23])[N:22]=2)[CH:4]=1.[Cl-].[NH+]1C=CC=CC=1>O>[CH3:23][C:21]1[N:22]=[C:18]([C:5]2[CH:4]=[C:3]([OH:2])[CH:8]=[C:7]([C:9]3[S:10][CH:11]=[C:12]([C:14]([F:16])([F:15])[F:17])[N:13]=3)[N:6]=2)[S:19][CH:20]=1

参加物

4

反応物 2

HCID 69401Einecs 211-027-4HCID 681599974-Methoxy-2-(4-methyl-thiazol-2-yl)-6-(4-trifluoromethyl-thiazol-2-yl)-pyridine

生成物 1

HCID 178431895HCID 178431895、化合物収率 72%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
200 °C

実験手順

A mixture of compound 22 (1.68 mmol) and pyridinium chloride (5 g/mmol) was heated at 200° C. with stirring. After 30 min, the reaction mixture was cooled down to room temperature and H2O was added. The solid was collected, washed with H2O, and dried to give compound 23 as a grey solid in 72% yield. MS (ESI, EI+): m/z=343.85 (MH+

後処理

  1. temperaturethe reaction mixture was cooled down to room temperature
  2. customThe solid was collected
  3. washwashed with H2O
  4. customdried

出典と根拠

ORDレコード
ord-079761f1ada8495e84cf02a2d56ba7ad
出典データセット
uspto-grants-2016_05
特許番号
US09353100B2

反応ノート

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