Dimethyl Sulfide → DMS bupivacaine

HRID 53078

反応式

HRID 53078 の反応式
[CH3:1][S:2][CH3:3].[CH3:4][CH2:5][CH2:6][CH2:7][N:8]1[CH:13]([C:14]([NH:16][C:17]2[C:18]([CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9]1>C(O)C>[CH3:1][S:2][CH3:3].[CH3:4][CH2:5][CH2:6][CH2:7][N:8]1[CH:13]([C:14]([NH:16][C:17]2[C:18]([CH3:24])=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:23])=[O:15])[CH2:12][CH2:11][CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 1068Dimethyl SulfideHCID 2474Bupivacaine (USAN:INN:BAN)

生成物 1

HCID 131719970DMS bupivacaine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

A uniform mixture of DMS and bupivacaine was formed by combining DMS dissolved in 95% ethanol with bupivacaine dissolved in 95% ethanol. The solution was air-dried under the hood at room temperature until the ethanol evaporated and left behind a well-dispersed mixture of dry crystalline DMS and bupivacaine. The crystalline mixture was pulverized under mortar and pestle and combined with copolymer. The rest of the procedures followed those described for CHP PLAMs. All DMS/bupivacaine PLAMs were synthesized using large bore Teflon® tubing.

後処理

  1. dry with materialThe solution was air-dried under the hood at room temperature until the ethanol
  2. customevaporated
  3. waitleft behind a well-dispersed mixture of dry crystalline DMS and bupivacaine

出典と根拠

ORDレコード
ord-bea38d61458940fea2cd3e1c387f5571
出典データセット
uspto-grants-1997_04
特許番号
US05618563

関連ノート

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