Methanol → methyl 1-methyl-1H-pyrazole-3-carboxylate
反応式
[C:1](=[O:4])([OH:3])N.[N:5]1[N:9]2[CH:10]=CC=C[C:8]2=[C:7](C(OC)=O)[CH:6]=1.S(=O)(=O)(O)O.[CH3:23]O>>[CH3:10][N:9]1[CH:8]=[CH:7][C:6]([C:1]([O:3][CH3:23])=[O:4])=[N:5]1参加物
4
実験手順
To a solution of compound 1 (1.26 g, 10 mmol) in methanol (30 mL) was added sulfuric acid (0.5 mL). The resulting mixture was refluxed for 2 h and the solvent was evaporated. The residue was dissolved in EA (60 mL) and washed with brine, dried over Na2SO4. Then filtered and concentrated to give the product.
後処理
- temperatureThe resulting mixture was refluxed for 2 h
- customthe solvent was evaporated
- dissolutionThe residue was dissolved in EA (60 mL)
- washwashed with brine
- dry with materialdried over Na2SO4
- filtrationThen filtered
- concentrationconcentrated
- customto give the product
出典と根拠
- ORDレコード
- ord-f3dbd1453946429894a2b8a33962d031
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09353104B2
反応ノート
読み込み中…