Phosphorus tribromide → 5-(bromomethyl)-3-ethyl-1-methyl-1H-pyrazole
反応式
[CH2:1]([C:3]1[CH:7]=[C:6]([CH2:8]O)[N:5]([CH3:10])[N:4]=1)[CH3:2].P(Br)(Br)[Br:12]>C(Cl)Cl>[Br:12][CH2:8][C:6]1[N:5]([CH3:10])[N:4]=[C:3]([CH2:1][CH3:2])[CH:7]=1参加物
4
実験手順
To a solution of compound 4 (500 mg, 3.57 mmol) in DCM (20 mL) was added PBr3 (386 mg, 1.43 mmol) was stirred at ° C. for 2 h. The mixture was washed with water, dried over Na2SO4. The solvent was evaporated to give the crude compound which was used in the next step without further purification.
後処理
- washThe mixture was washed with water
- dry with materialdried over Na2SO4
- customThe solvent was evaporated
出典と根拠
- ORDレコード
- ord-eada8e7c7393451a9f3883cce36f557a
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09353104B2
反応ノート
読み込み中…