Hydrochloric Acid → Methyl 3-aminocyclohexane-1-carboxylate
反応式
C(OC([NH:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]([O:17][CH3:18])=[O:16])[CH2:10]1)=O)(C)(C)C.Cl.CO>O1CCOCC1>[NH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH:11]([C:15]([O:17][CH3:18])=[O:16])[CH2:10]1参加物
5
実験手順
In a flask, methyl 3-(tert-butoxycarbonylamino)cyclohexanecarboxylate (5.13 g, 19.94 nmol) in 1,4-dioxane (15 ml) was reacted with hydrochloric acid in dioxane (4M) (15 mL). Methanol (2 mL) was added to aid in solubility. The reaction was stirred at room temperature for 1 hour. Upon completion the reaction was concentrated, and the crude (3.86 g) was progressed to the next step without further purification.
後処理
- concentrationUpon completion the reaction was concentrated
- customthe crude (3.86 g) was progressed to the next step without further purification
出典と根拠
- ORDレコード
- ord-ba9c3c9dc6bf4702a9729a199abefd56
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09351965B2
反応ノート
読み込み中…