Benzophenone imine → Methyl 3-(diphenylmethyleneamino)cyclohexanecarboxylate

HRID 530872ノート

反応式

HRID 530872 の反応式
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([O:10][CH3:11])=[O:9])[CH2:3]1.[C:12](=N)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>ClCCl>[C:13]1([C:12](=[N:1][CH:2]2[CH2:7][CH2:6][CH2:5][CH:4]([C:8]([O:10][CH3:11])=[O:9])[CH2:3]2)[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

参加物

4

反応物 2

HCID 136809Benzophenone imineHCID 13216966Methyl 3-aminocyclohexane-1-carboxylate

生成物 1

HCID 86698247Methyl 3-(diphenylmethyleneamino)cyclohexanecarboxylate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In a flask, methyl 3-aminocyclohexanecarboxylate (3.86 g, 19.94 mmol) was dissolved in dichloromethane (80 mL). Benzophenone imine (3.33 mL, 19.94 mmol) was added to the reaction, and the reaction was stirred at room temperature for 24 hrs. Upon completion, the reaction was concentrated and triturated with diethyl ether. The suspension was filtered. This trituration process was done twice. The remaining filtrate was concentrated and progressed to the next step without further purification.

後処理

  1. concentrationUpon completion, the reaction was concentrated
  2. customtriturated with diethyl ether
  3. filtrationThe suspension was filtered
  4. concentrationThe remaining filtrate was concentrated
  5. customprogressed to the next step without further purification

出典と根拠

ORDレコード
ord-2d8b0faaa1744303bd7cbe87e74a3fe9
出典データセット
uspto-grants-2016_05
特許番号
US09351965B2

反応ノート

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