Hydrochloric Acid → 3-(2-Fluorobenzyl)-3-(methoxymethyl)piperidine

HRID 530885ノート

反応式

HRID 530885 の反応式
Cl.[F:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][C:6]1([CH2:19][O:20][CH3:21])[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1>O1CCOCC1>[F:2][C:3]1[CH:25]=[CH:24][CH:23]=[CH:22][C:4]=1[CH2:5][C:6]1([CH2:19][O:20][CH3:21])[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67982981tert-Butyl 3-(2-fluorobenzyl)-3-(methoxymethyl)piperidine-1-carboxylate

生成物 1

HCID 679832113-(2-Fluorobenzyl)-3-(methoxymethyl)piperidine

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

Hydrochloric acid in dioxane (1.5 mL, 4M) was added to a flask containing tert-butyl 3-(2-fluorobenzyl)-3-(methoxymethyl)piperidine-1-carboxylate (0.415 g, 1.23 mmol). 1,4-dioxane (1.5 mL) was added to the reaction mixture. The reaction was allowed to stir for 4 hours. Upon reaction completion, the reaction was concentrated, and 337 mg of crude product was recovered and progressed to the next step without further purification.

後処理

  1. customUpon reaction completion
  2. concentrationthe reaction was concentrated
  3. custom337 mg of crude product was recovered
  4. customprogressed to the next step without further purification

出典と根拠

ORDレコード
ord-b356c715e813422683ff34ee5596f4b2
出典データセット
uspto-grants-2016_05
特許番号
US09351965B2

反応ノート

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