化工社化工社 化学情報印刷レポート · 研究参考用
Pyridine → HCID 71246821、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | 3-Chloropyridine-2-carboxylic acid | HCID 824632 | — |
| 反応物 | HCID 67981568 | HCID 67981568 | — |
| 触媒 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 71246821 | HCID 71246821 | 121.4% |
反応手順
To a mixture of 5-iodo-N2-methyl-pyridin-2,3-diamine (1.9 g) and pyridine (6 ml) were added WSC (1.28 g), HOBt (86 mg) and 3-chloro-pyridin-2-carboxylic acid (1.3 g), and the mixture was stirred at room temperature for 9 hours. To this reaction mixture was added water, and the mixture was filtered to collect the precipitated powder. The collected powder was washed with chloroform to give 3-chloro-pyridin-2-carboxylic acid (5-iodo-2-methylamino-pyridin-3-yl)-amide (3.6 g), which is hereinafter referred to as “intermediate compound (M20-7)”.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09353110B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-5b5386473848492683f605376c221684 |
| 出典メモ | uspto-grants-2016_05 |