2-Cyano-6-methoxy benzothiazole → 2-Cyano-6-hydroxybenzothiazole

HRID 530935

反応式

HRID 530935 の反応式
C[O:2][C:3]1[CH:13]=[CH:12][C:6]2[N:7]=[C:8]([C:10]#[N:11])[S:9][C:5]=2[CH:4]=1.Cl.[NH+]1C=CC=CC=1>>[OH:2][C:3]1[CH:13]=[CH:12][C:6]2[N:7]=[C:8]([C:10]#[N:11])[S:9][C:5]=2[CH:4]=1

参加物

3

反応物 2

HCID 3421092-Cyano-6-methoxy benzothiazoleHCID 21584435Pyridinium hydrochloride

生成物 1

HCID 98819122-Cyano-6-hydroxybenzothiazole収率 45%

反応条件

温度
190 °C

実験手順

A mixture of 6-methoxybenzo[d]thiazole-2-carbonitrile (1.0 g, 5.3 mmol) and dry pyridinium hydrochloride (11.3 g, 98.1 mmol) was stirred at 190° C. for 3 h. After the completion of reaction, it was cooled to room temperature to obtain a yellow solid. This solid was purified by flash chromatography (silica gel, methylene chloride/ethyl acetate=25/1) to afford 6-hydroxybenzo[d]thiazole-2-carbonitrile as a yellow solid (0.42 g, 45%). 1H-NMR (DMSO-d6, 300 MHz): δ 10.20 (s, 1H), 8.70 (m, 1H), 8.45 (m, 1H), 8.10 (m, 1H) ppm; MS (ESI): 177.1 (M+1).

後処理

  1. customAfter the completion of reaction, it
  2. temperaturewas cooled to room temperature
  3. customto obtain a yellow solid
  4. customThis solid was purified by flash chromatography (silica gel, methylene chloride/ethyl acetate=25/1)

出典と根拠

ORDレコード
ord-ebebb1a802a44e6fa528c96d4fd79f62
出典データセット
uspto-grants-2016_05
特許番号
US09353111B2

関連ノート

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