Dimethylformamide → 2-Bromo-4'-fluoro-5-methoxybiphenyl-4-carbaldehyde

HRID 531048ノート

反応式

HRID 531048 の反応式
[Br:1]N1C(=O)NC(=O)N(Br)C1=O.CN(C=O)C.[F:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([CH:30]=[O:31])=[C:26]([O:32][CH3:33])[CH:25]=2)=[CH:20][CH:19]=1>O>[Br:1][C:29]1[CH:28]=[C:27]([CH:30]=[O:31])[C:26]([O:32][CH3:33])=[CH:25][C:24]=1[C:21]1[CH:20]=[CH:19][C:18]([F:17])=[CH:23][CH:22]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 192912Dibromoisocyanuric acidHCID 225667274'-Fluoro-3-methoxy-[1,1'-biphenyl]-4-carbaldehyde

生成物 1

HCID 904235612-Bromo-4'-fluoro-5-methoxybiphenyl-4-carbaldehyde収率 180.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Dibromoisocyanuric acid (10.6 g) was added at 15° C. to 30° C. to a DMF (90 mL) solution of 4′-fluoro-3-methoxybiphenyl-4-carbaldehyde (16.0 g), and the mixture was stirred for 40 minutes. Then, water (30 mL) was added thereto, and the mixture was further stirred for 1 hour. The deposited solid was collected by filtration and washed with a mixed solution of DMF (15 mL) and water (15 mL) and water (30 mL) in this order to obtain the title compound (20.6 g).

後処理

  1. stirringthe mixture was further stirred for 1 hour
  2. filtrationThe deposited solid was collected by filtration
  3. washwashed with a mixed solution of DMF (15 mL) and water (15 mL) and water (30 mL) in this order

出典と根拠

ORDレコード
ord-8b661be5d8f44d37bb8fe0c8b0d3bf69
出典データセット
uspto-grants-2016_05
特許番号
US09353108B2

反応ノート

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