4,5-Dicyclopropyl-2-ethoxybenzenemethanol → 4,5-Dicyclopropyl-2-ethoxybenzaldehyde

HRID 531055ノート

反応式

HRID 531055 の反応式
[CH:1]1([C:4]2[C:9]([CH:10]3[CH2:12][CH2:11]3)=[CH:8][C:7]([CH2:13][OH:14])=[C:6]([O:15][CH2:16][CH3:17])[CH:5]=2)[CH2:3][CH2:2]1>[O-2].[O-2].[Mn+4].C1(C)C=CC=CC=1>[CH:1]1([C:4]2[C:9]([CH:10]3[CH2:12][CH2:11]3)=[CH:8][C:7]([CH:13]=[O:14])=[C:6]([O:15][CH2:16][CH3:17])[CH:5]=2)[CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 904239324,5-Dicyclopropyl-2-ethoxybenzenemethanol

生成物 1

HCID 904236504,5-Dicyclopropyl-2-ethoxybenzaldehyde収率 95.2%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 1140Toluene溶媒

反応条件

温度
80 °C

実験手順

Manganese dioxide (8.50 g) was added at room temperature to a toluene (50 mL) solution of (4,5-dicyclopropyl-2-ethoxyphenyl)methanol (2.84 g) in a nitrogen atmosphere, and the mixture was stirred at 80° C. for 1 hour. The reaction mixture was filtered through celite, and then, the filtrate was concentrated. The obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain the title compound (2.68 g).

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated
  3. customThe obtained residue was purified by silica gel column chromatography (hexane/ethyl acetate)

出典と根拠

ORDレコード
ord-77514b2c7a8641898ea80573a13b4059
出典データセット
uspto-grants-2016_05
特許番号
US09353108B2

反応ノート

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