Bromotrimethylsilane → 2-[3-Methoxy-4-hydroxy-1-naphthyl]ethane-1,1-diphosphonic Acid

HRID 53111ノート

反応式

HRID 53111 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:14][CH:15]([P:24]([O:29]CC)(=[O:28])[O:25]CC)[P:16]([O:21]CC)(=[O:20])[O:17]CC)[C:6]2[C:11]([C:12]=1[OH:13])=[CH:10][CH:9]=[CH:8][CH:7]=2.C[Si](Br)(C)C>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:14][CH:15]([P:16]([OH:21])(=[O:17])[OH:20])[P:24]([OH:29])(=[O:25])[OH:28])[C:6]2[C:11]([C:12]=1[OH:13])=[CH:10][CH:9]=[CH:8][CH:7]=2

参加物

3

反応物 2

HCID 76113BromotrimethylsilaneHCID 19961540Tetraethyl 2-[3-methoxy-4-hydroxy-1-naphthyl]ethane-1,1-diphosphonate

生成物 1

HCID 199615412-[3-Methoxy-4-hydroxy-1-naphthyl]ethane-1,1-diphosphonic Acid収率 67%

実験手順

Following the same method as described in Example 2, 7.12 g (15 mmol) of the tetraethyl 2-[3-methoxy-4-hydroxy-1-naphthyl]ethane-1,1-diphosphonate obtained in Example 11 was treated with trimethylsilyl bromide, and then hydrolysis was effected to obtain 3.64 g of the title compound as pale yellow crystals. The yield was m.p.: 231°-232° C. (dec)

後処理

  1. customhydrolysis

出典と根拠

ORDレコード
ord-00ba5370c0644f2eafdeac11cb470d44
出典データセット
uspto-grants-1997_04
特許番号
US05618804

反応ノート

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