Sulfuric Acid → Methyl beta-D-ribofuranoside

HRID 531223

反応式

HRID 531223 の反応式
[O:1]=[CH:2][C@@H:3]([C@@H:5]([C@@H:7]([CH2:9][OH:10])[OH:8])[OH:6])[OH:4].S(=O)(=O)(O)O.[C:16](=O)([O-])[O-].[Na+].[Na+]>CO>[O:1]([CH3:16])[C@@H:2]1[O:8][C@H:7]([CH2:9][OH:10])[C@@H:5]([OH:6])[C@H:3]1[OH:4]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 5311110Aldehydo-D-ribose

生成物 1

HCID 81983Methyl beta-D-ribofuranoside

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

5 g of D-Ribose was dissolved in 100 mL of methanol and cooled to 0° C. 0.5 mL of concentrated sulfuric acid was added and the solution was stored at −20° C. for 48 hrs. Solution was neutralized by passage through a bed of sodium carbonate and evaporated under vacuum to a viscous oil. Crude material was purified on a silica column eluting with 10% methanol in ethyl acetate to yield 2.1 grams of methyl β-D-ribofuranoside.

後処理

  1. customevaporated under vacuum to a viscous oil
  2. customCrude material was purified on a silica column
  3. washeluting with 10% methanol in ethyl acetate

出典と根拠

ORDレコード
ord-bc8569f33aa94875a5ee60292bbbc29f
出典データセット
uspto-grants-2016_05
特許番号
US09353133B2

関連ノート

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