関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Hydroxybenzophenone | HCID 14347 | — |
| 反応物 | 2,2-Bis(bromomethyl)-1,3-propanediol | HCID 18692 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | [3-(Bromomethyl)oxetan-3-yl]methanol | HCID 529264 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (4-{[3-(Hydroxymethyl)oxetan-3-yl]methoxy}phenyl)(phenyl)methanone | HCID 89906737 | — |
反応手順
Dissolve 4-hydroxybenzophenone in anhydrous THF and treat it with equimolar quantity of sodium hydride at 0° C. for 2 h. Stir and warm the suspension to 50° C. and treat it with an equimolar quantity of 3-Bromomethyl-3-hydroxymethyloxetane (readily prepared in one step by method described in U.S. Pat. No. 5,489,700 or Tet. Lett. 2011, 52, p. 565-567 from commercially available 2,2-bis-(bromomethyl)propane-1,3-diol). Stir overnight at 50° C., filter the reaction mixture, evaporate the filtrate to dryness and purify the residue by column chromatography to provide (4-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}phenyl)(phenyl)methanone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09353211B2 |
|---|
| 出典データセット | uspto-grants-2016_05 |
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| ORD ID | ord-96ea51ed7379461cb89c0e2a7f1e00f0 |
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| 出典メモ | uspto-grants-2016_05 |
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