Methanol → 3-Methoxy-3-oxo-2-phenylpropanoic acid

反応式

[C:1]1([CH:7]([C:11]([OH:13])=[O:12])[C:8]([OH:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.B(F)(F)F.[CH3:18]COCC.CO>>[C:1]1([CH:7]([C:11]([OH:13])=[O:12])[C:8]([O:10][CH3:18])=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

反応物 3

HCID 887Methanol

HCID 8000Boron trifluoride etherate

HCID 75791Phenylmalonic acid

生成物 1

HCID 28177753-Methoxy-3-oxo-2-phenylpropanoic acid

実験手順

A mixture of phenylmalonic acid (3.6 g, 0.02 mol), boron trifluoride etherate (2.4 mL, 0.02 mol) and 0.8 mL of anhydrous methanol (0.02 mol) was refluxed and stirred for 24 hours. After cooling to room temperature, the reaction mixture was filtered and 20 mL of water was added.