Hydrochloric Acid → 2(3H)-Thiazolimine, 5-methyl-3-[3-(trifluoromethyl)phenyl]-

HRID 5322

反応式

HRID 5322 の反応式
C([N:4]=[C:5]1[N:9]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[CH:11]=2)[CH:8]=[C:7]([CH3:20])[S:6]1)(=O)C.Cl>C(O)C.O>[NH:4]=[C:5]1[N:9]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([F:19])([F:17])[F:18])[CH:11]=2)[CH:8]=[C:7]([CH3:20])[S:6]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 152396782-(Acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline

生成物 1

HCID 110215462(3H)-Thiazolimine, 5-methyl-3-[3-(trifluoromethyl)phenyl]-収率 46.5%

試薬・触媒・溶媒 1

HCID 19096565Water ethanol溶媒

実験手順

A mixture of 2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline (1 g) and hydrochloric acid (38 %, 4 ml) in ethanol-water (1:2, 15 ml) was refluxed for 3 hours. Ethanol was removed by distillation under reduced pressure, and the residue was neutralized with potassium carbonate, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 0.4 g of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound (xi)).

後処理

  1. temperaturewas refluxed for 3 hours
  2. customEthanol was removed by distillation under reduced pressure
  3. extractionextracted with ethyl acetate
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-27da8e1d973d4c9ba83f51d41249d0ee
出典データセット
uspto-grants-1993_09
特許番号
US05244863

関連ノート

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