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2-(2-Fluoropropoxy)-3-nitropyridine → 2-(2-Fluoropropoxy)pyridin-3-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(2-Fluoropropoxy)-3-nitropyridine | HCID 58413305 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(2-Fluoropropoxy)pyridin-3-amine | HCID 58413385 | — |
反応手順
2-(2-fluoropropoxy)-3-nitropyridine (199.97 mg) was dissolved in a mixture of THF (10 ml) and methanol (5 ml). Pd/C (20 mg) was added and the mixture was hydrogenated at room temperature for 4 h and 3 bar. The mixture was concentrated in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08853193B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-cc68b35ccd2f43699ae394ab4323f65f |
| 出典メモ | uspto-grants-2014_10 |