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Hydrochloric Acid → 4-(2-(2-Fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | Methyl-4-(2-(2-fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate | HCID 58413371 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(2-(2-Fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid | HCID 58413252 | — |
反応手順
To a solution of methyl-4-(2-(2-fluoropropoxy)pyridin-3-ylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylate (333 mg) in THF (10 ml) was added lithium hydroxide (1M; 8 ml) and the reaction stirred at room temperature overnight. The mixture was neutralized with HCl (1M; 8 ml) and concentrated in vacuo. The crude product was purified by chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08853193B2 |
| 出典データセット | uspto-grants-2014_10 |
| ORD ID | ord-cf4abd6e932e4f58a73f36371919bc75 |
| 出典メモ | uspto-grants-2014_10 |